Four people have been confirmed dead and 11 injured in a major crash along the Vineyards leg of Highway 2000 in St Catherine in the vicinity of the Spanish Town exit.
The police say two of the deceased are men and two are women.
Their identities have not yet been determined.
Eyewitnesses reported that a mini bus with passengers crashed into a small truck laden with hardware materials.
The impact sent the truck crashing into a sign along the highway while the mini bus flipped before coming to a halt in the median.